Orphaned and left in the desert as an infant, Evil Roy Slade grew up alone—save for his teddy bear—and mean. As an adult, he is notorious for being the "meanest villain in the West"—so he's thrown for quite a loop when he falls for sweet schoolteacher Betsy Potter. There's also Nelson L. Stool, a railroad tycoon, who, along with his dimwitted nephew Clifford (Henry Gibson), is trying to get revenge on Evil Roy Slade for robbing him.